3. Studies of Cancer in Experimental Animals
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چکیده
The Working Group that evaluated smokeless tobacco previously noted that the majority of the early studies evaluated at that time (IARC, 1985) had various deficiencies, such as lack of quantitative and qualitative information on the nature of tobacco extracts and the degree of extraction, insufficient length of treatment, small group sizes and, in some cases, lack of appropriate controls. Since that time, new studies have been published and are included in this section. The cumulative published evidence for carcinogenicity of smokeless tobacco in experimental animals is summarized below and has also been reviewed recently (Hoffmann & Djordjevic, 1997; Grasso & Mann, 1998).
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